Whole-Genome Sequencing Analysis of Sapovirus Detected in South Korea

نویسندگان

  • Hye Lim Choi
  • Chang-Il Suh
  • Seung-Won Park
  • Ji-Young Jin
  • Han-Gil Cho
  • Soon-Young Paik
  • Yury E Khudyakov
چکیده

Sapovirus (SaV), a virus residing in the intestines, is one of the important causes of gastroenteritis in human beings. Human SaV genomes are classified into various genogroups and genotypes. Whole-genome analysis and phylogenetic analysis of ROK62, the SaV isolated in South Korea, were carried out. The ROK62 genome of 7429 nucleotides contains 3 open-reading frames (ORF). The genotype of ROK62 is SaV GI-1, and 94% of its nucleotide sequence is identical with other SaVs, namely Manchester and Mc114. Recently, SaV infection has been on the rise throughout the world, particularly in countries neighboring South Korea; however, very few academic studies have been done nationally. As the first whole-genome sequence analysis of SaV in South Korea, this research will help provide reference for the detection of recombination, tracking of epidemic spread, and development of diagnosis methods for SaV.

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عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2015